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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PAK1
All Species:
42.73
Human Site:
Y285
Identified Species:
72.31
UniProt:
Q13153
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13153
NP_001122092.1
545
60647
Y285
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
Chimpanzee
Pan troglodytes
XP_508657
536
59744
Y285
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
Rhesus Macaque
Macaca mulatta
XP_001090077
545
60664
Y285
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
Dog
Lupus familis
XP_849651
544
60649
Y284
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
Cat
Felis silvestris
Mouse
Mus musculus
O88643
545
60718
Y285
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
Rat
Rattus norvegicus
P35465
544
60559
Y284
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509462
527
58159
L285
V
A
I
K
Q
M
N
L
Q
Q
Q
P
K
K
E
Chicken
Gallus gallus
NP_001155844
544
60631
Y284
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
Frog
Xenopus laevis
NP_001079232
564
62749
Y303
Q
G
A
S
G
T
V
Y
T
A
I
D
I
A
T
Zebra Danio
Brachydanio rerio
NP_958485
577
63243
E284
K
K
K
M
S
D
E
E
I
L
E
K
L
R
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXE5
639
69601
C383
E
G
S
T
G
T
V
C
I
A
T
D
K
S
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17850
572
63863
Y310
S
G
A
S
G
S
V
Y
T
A
I
E
I
S
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03497
939
102344
Y635
Q
G
A
S
G
G
V
Y
T
A
Y
E
I
G
T
Red Bread Mold
Neurospora crassa
Q7RZD3
954
103773
Y689
Q
G
A
S
G
G
V
Y
T
G
H
E
R
G
S
Conservation
Percent
Protein Identity:
100
94.3
99.6
96.6
N.A.
97.6
98.9
N.A.
78.7
94.5
80.6
81.9
N.A.
32.7
N.A.
54.7
N.A.
Protein Similarity:
100
95.2
99.6
97
N.A.
98.7
99
N.A.
85.3
96.8
88.3
87.8
N.A.
50.8
N.A.
68.7
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
100
86.6
0
N.A.
46.6
N.A.
60
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
0
100
100
20
N.A.
73.3
N.A.
93.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.5
32.7
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.6
43.8
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
66.6
53.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
80
66.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
79
0
0
0
0
0
0
79
0
0
0
58
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
0
0
0
0
0
65
0
0
0
% D
% Glu:
8
0
0
0
0
0
8
8
0
0
8
22
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
86
0
0
86
15
0
0
0
8
0
0
0
15
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
15
0
15
0
22
0
0
% I
% Lys:
8
8
8
8
0
0
0
0
0
0
0
8
15
8
0
% K
% Leu:
0
0
0
0
0
0
0
8
0
8
0
0
8
0
0
% L
% Met:
0
0
0
8
0
8
0
0
0
0
50
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% P
% Gln:
72
0
0
0
8
0
0
0
8
8
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% R
% Ser:
8
0
8
79
8
8
0
0
0
0
0
0
0
15
15
% S
% Thr:
0
0
0
8
0
65
0
0
79
0
8
0
0
0
79
% T
% Val:
8
0
0
0
0
0
86
0
0
0
0
0
50
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
79
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _